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Related Concept Videos

Blood and Nerve Supply to the Kidney01:18

Blood and Nerve Supply to the Kidney

The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of each...
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
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Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Introduction to Urinary System01:13

Introduction to Urinary System

The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
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Renal Regulation of Acid-Base Balance01:29

Renal Regulation of Acid-Base Balance

Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
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However, the intercalated cells in...

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Related Experiment Video

Updated: May 10, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Neural control of renal function.

Edward J Johns1, Ulla C Kopp, Gerald F DiBona

  • 1University College Cork, Physiology, Cork, Ireland.

Comprehensive Physiology
|June 6, 2013
PubMed
Summary
This summary is machine-generated.

The kidney

More Related Videos

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
11:08

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.

Published on: February 14, 2018

Related Experiment Videos

Last Updated: May 10, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
11:08

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.

Published on: February 14, 2018

Area of Science:

  • Nephrology
  • Neuroscience
  • Cardiovascular Physiology

Background:

  • The kidney's sympathetic innervation regulates renal function, impacting blood flow, filtration, and sodium/water balance.
  • Afferent sensory nerves in the kidney initiate renorenal reflexes that coordinate kidney function.
  • Dysregulation of renal sympathetic activity is implicated in hypertension and renal disease.

Purpose of the Study:

  • To elucidate the integrated roles of efferent and afferent renal sympathetic nerves in homeostasis and disease.
  • To explore the renorenal reflex mechanisms coordinating kidney function.
  • To investigate the therapeutic potential of renal denervation in hypertension.

Main Methods:

  • Review of physiological and pathophysiological roles of renal innervation.
  • Description of renorenal reflex pathways and feedback loops.
  • Reference to clinical studies on renal denervation for hypertension.

Main Results:

  • Efferent renal sympathetic activity modulates renal hemodynamics, tubular reabsorption, and renin release.
  • Afferent sensory nerves trigger inhibitory renorenal reflexes, promoting natriuresis and diuresis.
  • Renal denervation has shown promise in reducing arterial pressure in hypertensive patients.

Conclusions:

  • The renal nervous system is crucial for maintaining sodium and water homeostasis.
  • Renorenal reflexes coordinate kidney function to prevent excessive sodium retention.
  • Targeting renal sympathetic nerves, e.g., via denervation, may offer a therapeutic strategy for hypertension.