Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rhesus macaques with an <i>OPA1</i> mutation demonstrate features of autosomal dominant optic atrophy.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Extravascular Motion Signal Detected by OCT Angiography Indicates Altered Vascular-Tissue Biomechanical Interactions in Glaucoma.

Investigative ophthalmology & visual science·2026
Same author

Optic Nerve Head Spatial Transcriptomic Change in Nonhuman Primate Early Experimental Glaucoma.

Investigative ophthalmology & visual science·2026
Same author

Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma.

Investigative ophthalmology & visual science·2026
Same author

Global Glaucoma Prevalence: Burden and Projection to 2060.

American journal of ophthalmology·2025
Same author

Relations Between Pulsatility in the Optic Nerve Head or Peripapillary Retinal Vessels and the Rate of Progression in Glaucoma.

Investigative ophthalmology & visual science·2025
Same journal

New Guidelines for Ophthalmic Genetic Studies.

Investigative ophthalmology & visual science·2026
Same journal

Genomic Copy Number Variants Associated With Strabismus and Amblyopia in the All of Us Research Program.

Investigative ophthalmology & visual science·2026
Same journal

Xanthophyll Carotenoid Intake, Plasma Levels, and Retinal Visualization in Aging and Age-Related Macular Degeneration: ALSTAR2.

Investigative ophthalmology & visual science·2026
Same journal

Enhanced Endocytosis and Mitochondrial Stress Underlie Severe Retinitis Pigmentosa With RHO P347L Mutant.

Investigative ophthalmology & visual science·2026
Same journal

Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus.

Investigative ophthalmology & visual science·2026
Same journal

Psychometric Performance of Children With Amblyopia During a Tablet-Based Adaptive Visual Acuity Assessment.

Investigative ophthalmology & visual science·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Longitudinal hemodynamic changes within the optic nerve head in experimental glaucoma.

Grant Cull1, Claude F Burgoyne, Brad Fortune

  • 1Devers Eye Institute, Legacy Research Institute, Portland, Oregon, USA.

Investigative Ophthalmology & Visual Science
|June 6, 2013
PubMed
Summary
This summary is machine-generated.

In experimental glaucoma, optic nerve head blood flow initially increases during early damage but then linearly declines as retinal nerve fiber layer thickness is lost. This two-phase pattern correlates with glaucoma progression.

Keywords:
blood flowexperimental glaucomaintraocular pressureoptic nerve head

More Related Videos

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Related Experiment Videos

Last Updated: May 10, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Ocular Blood Flow

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Optic nerve head (ONH) blood flow (BF) changes may precede structural damage in glaucoma.
  • Understanding these changes is crucial for early diagnosis and treatment.

Purpose of the Study:

  • To characterize longitudinal changes in basal ONH BF during structural damage progression in experimental glaucoma (EG).
  • To investigate the relationship between ONH BF alterations and retinal nerve fiber layer thickness (RNFLT) loss.

Main Methods:

  • Unilateral experimental glaucoma induced by laser trabecular meshwork treatment in rhesus macaques.
  • Biweekly measurements of intraocular pressure (IOP), RNFLT, and ONH BF using spectral-domain optical coherence tomography and laser speckle flowgraphy.
  • Longitudinal analysis of BF changes relative to RNFLT loss and control eyes.

Main Results:

  • EG eyes showed elevated IOP compared to controls (20.2 ± 5.9 vs. 12.3 ± 2.6 mm Hg).
  • Basal ONH BF initially increased by 9% ± 10% in early EG (RNFLT loss < 10%) but subsequently declined by up to 25.0% ± 9.6% in later stages.
  • ONH BF changes strongly correlated with RNFLT loss (average r = 0.81), showing a two-phase pattern.

Conclusions:

  • Experimental glaucoma exhibits a two-phase pattern of ONH BF alteration.
  • An initial increase in ONH BF is followed by a linear decline strongly correlated with RNFLT loss.
  • These findings highlight dynamic vascular changes during glaucoma progression.