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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
Flash electroretinography and pattern visual evoked potential changes in ocular hypertension patients
Ercüment Cavdar1, Abdullah Ozkaya, Burcu Alper
1Kemalpaşa State Hospital, Clinic of Ophthalmology, 35730 Izmir, Turkey.
Journal of Ophthalmology
|June 6, 2013
Summary
Ocular hypertension patients show reduced oscillatory potentials (Ops) amplitude in flash electroretinography (fERG) and pattern visual evoked potentials (pVEP) amplitude. These changes may indicate early glaucomatous damage.
Area of Science:
- Ophthalmology
- Neuroscience
Background:
- Ocular hypertension (OHT) is a risk factor for glaucoma.
- Early detection of glaucomatous damage is crucial for timely intervention.
Purpose of the Study:
- To assess changes in flash electroretinography (fERG) and pattern visual evoked potentials (pVEP) in OHT patients.
- To identify electrophysiological markers indicative of early glaucomatous damage.
Main Methods:
- Cross-sectional study involving 25 OHT patients and 30 healthy volunteers.
- Comprehensive ophthalmologic examinations, visual field tests, pVEP, and fERG were performed.
- Comparison of pVEP and fERG parameters between OHT patients and controls.
Main Results:
- OHT patients exhibited a statistically significant lower mean amplitude of pVEP (P < 0.05).
- Significant decrease in oscillatory potentials (Ops) amplitude and delayed latency of rod and cone waves in fERG of OHT group (all P < 0.05).
- No significant changes were observed in flicker fERG waves between groups (P > 0.05).
Conclusions:
- A decrease in Ops amplitude in fERG and pVEP amplitude may serve as early indicators of glaucomatous damage in OHT patients.
- Ops amplitude reduction was the most statistically significant finding differentiating OHT patients from controls.
