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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: May 10, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Cell-based therapy for ischemic stroke.

Jing Zhang1, Michael Chopp

  • 1Department of Neurology, Henry Ford Health System, Education & Research Building, #3056, 2799 West Grand Boulevard, Detroit, MI 48202, USA. jingz@neuro.hfh.edu

Expert Opinion on Biological Therapy
|June 7, 2013
PubMed
Summary
This summary is machine-generated.

Cell-based therapy shows promise for stroke recovery by enhancing the brain's natural repair processes. This approach aims to promote neuroplasticity and angiogenesis, rather than replacing damaged cells.

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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

Related Experiment Videos

Last Updated: May 10, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Biology

Background:

  • Stroke is a leading cause of adult mortality and disability globally.
  • Current stroke treatments have limited therapeutic windows and lack effective neuroprotection.
  • The central nervous system (CNS) initiates endogenous repair mechanisms post-stroke, including neurogenesis and angiogenesis.

Purpose of the Study:

  • To review current knowledge on cell-based therapy for adult brain stroke.
  • To examine transplanted cell types, their benefits, and risks.
  • To emphasize the mechanisms of action for cell-based therapies.

Main Methods:

  • Review of experimental studies and clinical trials.
  • Analysis of transplanted cell types and their effects.
  • Evaluation of therapeutic benefits, risks, and mechanisms.

Main Results:

  • Experimental and clinical data suggest cell-based therapy is a promising approach for stroke.
  • Cell-based therapy promotes CNS remodeling through neuroplasticity, angiogenesis, and immunomodulation.
  • The primary goal is not cell replacement but enhancement of endogenous repair mechanisms.

Conclusions:

  • Cell-based therapy offers a novel strategy to improve functional outcomes after stroke.
  • Further evaluation of potential risks is crucial before widespread clinical application.
  • This therapy leverages the brain's inherent capacity for repair and recovery.