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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...

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Related Experiment Video

Updated: May 10, 2026

Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials
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Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials

Published on: March 7, 2025

Gradient biomaterials and their influences on cell migration.

Jindan Wu1, Zhengwei Mao, Huaping Tan

  • 1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering , Zhejiang University , Hangzhou 310027 , People's Republic of China.

Interface Focus
|June 7, 2013
PubMed
Summary

This review explores how engineered biomaterials with physical, chemical, and biological gradients can guide cell migration. This approach is crucial for advancing regenerative medicine and tissue regeneration.

Keywords:
biointerfacesbiomaterialscell migrationgradientregenerative medicine

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Last Updated: May 10, 2026

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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cell Biology

Background:

  • Cell migration is vital for development, wound healing, and disease.
  • Cells navigate using chemical and physical cues from their environment.
  • Controlling cell migration is key for effective regenerative medicine.

Purpose of the Study:

  • To review in vivo gradients and their effects on cell migration.
  • To summarize advancements in gradient biomaterials for controlling cell behavior.
  • To highlight the role of these materials in tissue regeneration.

Main Methods:

  • Review of existing literature on in vivo gradients.
  • Analysis of fabrication techniques for gradient biomaterials.
  • Discussion of how gradients influence cell migration.

Main Results:

  • In vivo environments present complex gradients influencing cell movement.
  • Engineered biomaterials can mimic these gradients to direct cell behavior.
  • Gradient biomaterials offer precise control over cell migration for tissue engineering.

Conclusions:

  • Gradient biomaterials are essential for mimicking in vivo complexity in regenerative medicine.
  • Understanding gradient mechanisms is critical for designing advanced tissue regenerative materials.
  • Future trends focus on programmed cell migration for long-term tissue regeneration goals.