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Updated: May 10, 2026
09:06
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
Insights in microRNAs biology
Antonios N Gargalionis1, Efthimia K Basdra
1Cellular and Molecular Biomechanics Unit, Department of Biological Chemistry, Medical School, University of Athens, 75, M. Asias Street, 11527 Athens, Greece.
Current Topics in Medicinal Chemistry
|June 11, 2013
Summary
MicroRNAs (miRNAs) are small RNAs regulating gene expression. Their dysregulation is implicated in numerous diseases, offering potential for diagnostics and therapeutics.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- MicroRNAs (miRNAs) are small, non-coding RNAs acting as post-transcriptional gene regulators.
- They influence a significant portion of the human transcriptome, impacting gene expression.
- miRNAs are crucial in development, organogenesis, and cellular responses to stress.
Purpose of the Study:
- To provide an overview of miRNA biogenesis and function.
- To highlight the role of miRNAs in human development and disease.
- To discuss the potential of miRNAs as biomarkers and therapeutic targets.
Main Methods:
- Review of current literature on miRNA biology.
- Analysis of miRNA involvement in various human pathologies.
- Discussion of miRNA-based diagnostic and therapeutic strategies.
Main Results:
- miRNAs are generated through a two-step maturation process.
- Dysregulated miRNAs are linked to cancer, cardiovascular, metabolic, and neurodegenerative diseases.
- miRNAs can serve as extracellular biomarkers and are targets for inhibition or delivery therapies.
Conclusions:
- miRNAs are key regulators with significant roles in health and disease.
- Understanding miRNA pathways is vital for developing novel diagnostic and therapeutic approaches.
- miRNA-based strategies hold promise for personalized medicine.
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