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Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...

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Related Experiment Video

Updated: May 10, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

MicroRNAs in aortic disease.

Manolis Vavuranakis1, Maria Kariori, Dimitrios Vrachatis

  • 11st Dept. of Cardiology, Hippokration Hospital, Medical School, University of Athens, Greece. vavouran@otenet.gr

Current Topics in Medicinal Chemistry
|June 11, 2013
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators in cardiovascular development and disease. Their circulating levels serve as reliable biomarkers for various cardiac conditions, including aortic stenosis and aneurysm.

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Last Updated: May 10, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases
04:59

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Published on: June 20, 2025

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Science

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • miRNA maturation is critical for cardiovascular development, and dysregulation is linked to cardiac pathologies.
  • Circulating miRNA levels are stable, reliable biomarkers reflecting tissue alterations in cardiovascular diseases.

Purpose of the Study:

  • To review miRNA maturation and their role in cardiovascular development.
  • To explore miRNAs as biomarkers for cardiac diseases, including specific families involved in cardiac remodeling.
  • To examine miRNA involvement in aortic stenosis pathways and aortic aneurysm/dissection development.

Main Methods:

  • Literature review of miRNA maturation and function in cardiovascular systems.
  • Analysis of studies on circulating miRNA levels as disease biomarkers.
  • Categorization of miRNAs involved in aortic stenosis based on pathogenesis (inflammation, fibrosis, calcification).

Main Results:

  • miRNAs play crucial roles in cardiovascular development and are implicated in various cardiac pathologies.
  • Circulating miRNAs are valuable biomarkers for conditions like atherosclerosis, myocardial infarction, heart failure, and aortic stenosis.
  • Specific miRNA families are associated with cardiac remodeling and the pathogenesis of aortic stenosis, aneurysm, and dissection.

Conclusions:

  • miRNAs are integral to cardiovascular health and disease, acting as both regulators and biomarkers.
  • Understanding miRNA profiles offers insights into cardiovascular disease mechanisms and progression.
  • miRNAs hold potential for diagnostic and therapeutic strategies in cardiovascular medicine, particularly for aortic diseases.