Related Experiment Video
Updated: May 10, 2026

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
Published on: July 31, 2017
Neurological and Cardiovascular Potential of Pharmacologically Active Hydrazonone Derivatives
1Department of Pharmacy, Guru Ram Das (PG) IMT, Dehradun, (Uttarakhand), 248901, India.
Abstract:
Hydrazone derivatives possess an azomethine group and are considered as an important class of pharmacological active compounds and also created interest of researchers to synthesized variety of hydrazones derivatives having biological activities for new drug development. Hydrazones moieties are present in many pharmacological active molecules. which have been showed high interest because of their various types of diverse pharmacological, biological and clinical applications. Hydrazonones possess wide variety of biological activities such as antimicrobial, analgesic, anti-inflammatory, antiplatelet, antitubercular, anticancer, antiviral, antimalarial, anthelmintic, antifungal and antiparasitic etc. Various hydrazones possess neurological and cardiovascular activities. This is review focus on the neurological and cardiovascular activities of hydrazones compounds.
More Related Videos
04:48A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
Published on: July 10, 2018
07:02A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
Related Concept Videos
Antihypertensive Drugs: Vasodilators
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
Neurochemical Transmission: Sites of Drug Action
Drugs Affecting Neurotransmitter Synthesis
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...