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Updated: May 10, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside
Manami Kurisu1, Yusaku Miyamae, Kazuma Murakami
1Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan.
Abstract:
We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid β protein (Aβ42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of Aβ42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.
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