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Renal involvement in paroxysmal nocturnal hemoglobinuria
1Department of Nephrology, Aga Khan University Hospital Karachi, Karachi, Pakistan.
Nephron. Clinical Practice
|June 12, 2013
Summary
Paroxysmal nocturnal hemoglobinuria (PNH) can cause acute kidney injury (AKI), potentially leading to chronic kidney disease (CKD). Early PNH diagnosis and treatment are vital for preventing irreversible kidney damage and reducing healthcare costs.
Area of Science:
- Nephrology
- Hematology
- Internal Medicine
Background:
- Renal involvement in paroxysmal nocturnal hemoglobinuria (PNH) is often subclinical but can range from acute dysfunction to irreversible chronic kidney disease (CKD).
- CKD in PNH patients may necessitate renal replacement therapy, significantly burdening healthcare systems and families, especially in low-resource settings.
- Early diagnosis and intervention are crucial for preventing disease progression and managing PNH-related kidney complications.
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