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A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

Laboratory testing for platelet antibodies.

Nahla M Heikal¹, Kristi J Smock

¹Department of Pathology, University of Utah Health Sciences Center, and ARUP Laboratories Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA.

American Journal of Hematology

|June 13, 2013

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Laboratory tests identify platelet antibodies in immune-mediated thrombocytopenias. This review covers platelet antibody testing methods and their use in various conditions, including neonatal alloimmune thrombocytopenia and drug-induced thrombocytopenia.

Area of Science:

Immunology
Hematology
Clinical Laboratory Science

Background:

Immune-mediated thrombocytopenias are characterized by antibodies targeting platelets.
Accurate diagnosis relies on identifying and classifying these platelet-specific or drug-dependent antibodies.

Purpose of the Study:

To review current laboratory methods for detecting platelet antibodies.
To discuss the clinical applications of these tests in various thrombocytopenic disorders.

Main Methods:

Review of existing literature on platelet antibody detection assays.
Summary of techniques including antigen-specific assays, flow cytometry, and solid-phase methods.

Main Results:

Various assays exist for identifying antibodies in serum or bound to platelets.

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Testing is crucial for diagnosing conditions like neonatal alloimmune thrombocytopenia, post-transfusion purpura, and immune thrombocytopenia.

Conclusions:

Platelet antibody testing is essential for diagnosing and managing immune-mediated thrombocytopenias.
Understanding available testing modalities aids in appropriate patient management and treatment strategies.