[Spectral-luminescent study of pH-dependent conformational changes in fibrinogen]

Results are presented of measurements of fluorescence parameters of fibrinogen at pH values of 2-12. It is stated that the stability zone of native conformation of fibrinogen molecule lies in the pH range of 5,5-8,5. In an acid medium the fibrinogen molecule twice (in the pH range of 5--3 and 3--2) undergoes structural rearrangement. In an alkali medium the structural rearrangement of fibrinogen is observed at pH greater than 9,5.