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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Bis-chalcones and flavones: synthesis and antimicrobial activity
Asif Husain1, Mohd Rashid, Ravinesh Mishra
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, Hamdard Nagar, New Delhi-110062, India. drasifhusain@yahoo.com
Acta Poloniae Pharmaceutica
|June 14, 2013
Summary
Researchers synthesized novel bis-chalcone and flavone derivatives and tested their antimicrobial properties. Some compounds demonstrated significant antibacterial and antifungal activity against tested microbes.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Microbiology
Background:
- Chalcones and flavones are known classes of compounds with diverse biological activities.
- Exploring novel derivatives can lead to new antimicrobial agents.
- Bis-chalcones and flavones represent promising scaffolds for drug discovery.
Purpose of the Study:
- To synthesize a series of novel bis-chalcone and flavone derivatives.
- To evaluate the synthesized compounds for their antimicrobial activity.
- To identify potential lead compounds for antibacterial and antifungal drug development.
Main Methods:
- Bis-chalcones were synthesized via the Claisen-Schmidt condensation reaction.
- Flavones were prepared through oxidative cyclization of the synthesized bis-chalcones.
- Antimicrobial activity was assessed against selected bacterial and fungal strains.
Main Results:
- A series of bis-chalcones (3a-g) and flavones (4a-g) were successfully synthesized.
- Several synthesized compounds exhibited notable antibacterial and antifungal activities.
- The study identified specific derivatives with promising antimicrobial potential.
Conclusions:
- The synthesized bis-chalcone and flavone derivatives possess significant antimicrobial properties.
- These compounds represent potential candidates for further development as antimicrobial drugs.
- The study contributes to the search for novel agents to combat microbial infections.
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