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Updated: May 10, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
Published on: May 5, 2023
Proposed mechanism for the initiation of transposable element silencing by the RDR6-directed DNA methylation pathway
Kaushik Panda1, R Keith Slotkin
1Department of Molecular Genetics; The Ohio State University; Columbus, OH USA.
Abstract:
The activity of transposable elements is epigenetically suppressed by both transcriptional and post-transcriptional mechanisms. We recently identified a direct connection between the small RNA-mediated post-transcriptional mRNA degradation of actively transcribing transposable elements and the de novo methylation of transposable element DNA, providing a mechanistic link between these two established pathways of transposable element silencing. Here we provide a model for the initiation, establishment and epigenetic maintenance of transposable element silencing that incorporates recent data in this rapidly emerging field.
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