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End-joining, translocations and cancer.

Samuel F Bunting1, Andre Nussenzweig

  • 1Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA. bunting@cabm.rutgers.edu

Nature Reviews. Cancer
|June 14, 2013
PubMed
Summary

Fusion genes from chromosome translocations drive cancer cell growth. These complex rearrangements are common in tumors, with non-homologous end-joining a key factor in their formation.

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