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Published on: April 11, 2018
Open forward and inverse problems in theoretical modeling of bone tissue adaptation
1Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology, TU Delft, Mekelweg 2, Delft 2628 CD, The Netherlands.
Summary
This study reviews open problems in theoretical bone tissue adaptation modeling. It identifies four categories of challenges, highlighting largely overlooked areas for future research in this field.
Area of Science:
- Biomechanics
- Computational Biology
- Tissue Engineering
Background:
- Theoretical modeling of bone tissue adaptation has a long history.
- Significant progress has been made, yet many questions remain unanswered.
- Existing models often focus on specific aspects, leaving broader challenges unexplored.
Purpose of the Study:
- To provide an overview of open problems in theoretical bone tissue adaptation modeling.
- To categorize these open problems into forward and inverse challenges.
- To highlight and discuss the importance of largely overlooked research areas.
Main Methods:
- Definition and review of principal elements in bone adaptation models.
- Identification and categorization of open problems based on model elements.
- Discussion of the significance and implications of identified open problems.
Main Results:
- Four distinct categories of open problems were identified.
- Two categories focus on forward problems, and two on inverse problems.
- Most prior research concentrated on the first category of forward problems, neglecting others.
Conclusions:
- Significant gaps exist in the theoretical modeling of bone adaptation, particularly in inverse problems and less-studied forward problems.
- Further research is needed to address these overlooked areas.
- Inspiring new research avenues is crucial for advancing the field.
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