Related Experiment Video
Updated: May 10, 2026

11:44
Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Pnictogen-directed synthesis of discrete disulfide macrocycles
Mary S Collins1, Matthew E Carnes, Aaron C Sather
1University of Oregon and Materials Science Institute, Eugene, Oregon 97403-1253, USA.
Abstract:
Cyclic disulfide macrocycles were rapidly synthesized cleanly and selectively from rigid dithiols via oxidation with iodine when activated by pnictogen additives (As and Sb). Macrocycles were confirmed by (1)H-NMR spectroscopy and X-ray crystallography. A p-xylyl-based disulfide trimer and tetramer crystallized in hollow, stacked columns stabilized by intermolecular, sulfur···sulfur close contacts.

