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Updated: May 10, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Inter- relationship between rheumatoid arthritis and periodontitis
J Rajkarnikar1, B S Thomas, S K Rao
1Department of Periodontics and Implantology, College of Dental Sciences and Hospital- Nepal Medical College (CODSH- NMC), Attarkhel, Nepal.
Kathmandu University Medical Journal (KUMJ)
|June 19, 2013
Summary
Rheumatoid arthritis (RA) patients exhibit more severe periodontal disease, including bone loss and higher gingival index. Inflammatory markers like ESR and CRP correlate with periodontal disease severity, suggesting a shared inflammatory pathway.
Area of Science:
- Periodontal Medicine
- Immunology
- Rheumatology
Background:
- Periodontal medicine explores the link between oral health and systemic conditions.
- Periodontitis and Rheumatoid Arthritis (RA) may share common immune-inflammatory dysregulation.
Purpose of the Study:
- To investigate the association between periodontal disease and Rheumatoid Arthritis.
- To compare periodontal parameters in RA patients versus controls.
Main Methods:
- 100 patients were divided into 50 RA cases and 50 age/gender-matched controls.
- Periodontal health assessed via plaque index, gingival index, missing teeth, and bone loss.
- RA severity measured by health assessment questionnaires, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR).
Main Results:
- RA patients showed significantly more severe alveolar bone loss and higher gingival index compared to controls.
- Plaque index was similar between groups.
- ESR and CRP levels in RA patients were significantly associated with periodontal disease severity.
Conclusions:
- A significant association exists between Rheumatoid Arthritis and Periodontitis.
- This link may stem from a common underlying inflammatory response deregulation.
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