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Related Experiment Video

Updated: May 10, 2026

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
12:42

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

Published on: July 14, 2018

Genetic loci for retinal arteriolar microcirculation.

Xueling Sim1, Richard A Jensen, M Kamran Ikram

  • 1Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.

Plos One
|June 19, 2013
PubMed

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Summary

Researchers identified a novel genetic variant (rs2194025) associated with retinal arteriolar caliber, a potential indicator of vascular health. Further studies are needed to determine its clinical relevance for diseases like hypertension.

Area of Science:

  • Genetics
  • Ophthalmology
  • Cardiovascular Research

Background:

  • Retinal arteriolar narrowing is a predictor of hypertension and vascular diseases.
  • Microcirculatory flow resistance is implicated in these conditions.

Purpose of the Study:

  • To identify genetic factors influencing retinal arteriolar caliber.
  • To investigate the genetic determinants of microvascular variations.

Main Methods:

  • Genome-wide association study (GWAS) in over 18,000 individuals.
  • Meta-analysis of discovery cohorts and replication in independent cohorts.
  • Measurement of retinal vascular calibers from digitized retinal photographs.

Main Results:

  • One genetic variant, rs2194025 near the MEF2C gene, showed genome-wide significant association with retinal arteriolar caliber.

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Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes
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Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

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Last Updated: May 10, 2026

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
12:42

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

Published on: July 14, 2018

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes
10:46

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

Published on: October 7, 2018

  • This association was robustly replicated in independent cohorts.
  • No significant association was found with major clinical cardiovascular outcomes in secondary analyses.

    • Conclusions:

    • A novel genetic locus associated with retinal microvasculature variation has been identified.
    • The identified variant (rs2194025) contributes to genetic diversity in retinal vascular caliber.
    • The clinical significance of this genetic finding for vascular diseases requires further investigation.