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Published on: April 17, 2020
Retrospective cohort study of long-gap oesophageal atresia
Rajesh Maheshwari1, Amit Trivedi, Karen Walker
1Grace Centre for Newborn Care, The Children's Hospital, Sydney, New South Wales, Australia.
Insights
Infants with long-gap esophageal atresia (LGOA) face prolonged hospital stays and significant risks of growth failure. Close monitoring for developmental delays is crucial for these children.
Area of Science:
- Pediatric Surgery
- Neonatology
- Developmental Pediatrics
Background:
- Long-gap esophageal atresia (LGOA) is a rare congenital malformation.
- Management of LGOA presents unique challenges in neonates.
Purpose of the Study:
- To review short-term outcomes for infants with LGOA.
- To assess survival, hospital stay, complications, growth, and neurodevelopment.
Main Methods:
- Retrospective review of 101 esophageal atresia cases (2001-2011).
- 15 infants met LGOA criteria; data extracted from case notes.
- Included demographic, clinical, and follow-up developmental data.
Main Results:
- 80% survival rate; median hospital stay of 83 days.
- 60% had additional congenital anomalies.
- Majority experienced growth failure; all assessed infants showed abnormal neurodevelopment (Bayley-III), particularly in gross motor skills.
Conclusions:
- LGOA infants require extended hospitalization.
- Significant risk of growth failure during and after hospitalization.
- Potential for developmental delay necessitates vigilant monitoring.
Aim:
Long-gap oesophageal atresia (LGOA) remains a rare variant of a relatively common congenital malformation. Objectives of this study were to review the short-term results including survival, length of stay and post-operative complications for infants with LGOA managed at a single centre in addition to their growth and neurodevelopmental assessment.
Methods:
Retrospective review of the case notes of all infants admitted with oesophageal atresia to our institution from January 2001 to May 2011. Infants with LGOA were selected based on pre-defined criteria. Demographic and clinical variables and details of follow-up visits including developmental assessments were extracted from their case notes.
Results:
Of 101 infants with oesophageal atresia, 15 fulfilled the criteria for LGOA. Overall survival was 80%. Median length of stay was 83 days. Additional congenital anomalies were present in nine (60%). A fall in weight centile during hospitalisation or outpatient follow-up signifying growth failure was seen in a majority with 11 of 13 patients showing this phenomenon. Follow-up at our institution ranged from 6 months to 9 years. Developmental assessments (Bayley-III) commenced in August 2006 were available in four patients (age 5-13 months) and were abnormal in all, with particular delay in the gross motor domain.
Conclusions:
Infants with LGOA spend a long time in hospital. They remain at significant risk of growth failure during hospitalisation and following discharge. There appears to be a risk of developmental delay that warrants close monitoring.
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