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Cerebral demyelination in children with collagenous colitis
S Sankararaman1, M Osman, G Wellman
1WK Pediatric Gastroenterology and Research, Willis-Knighton Hospital, Shreveport, Louisiana, USA.
Journal of Postgraduate Medicine
|June 25, 2013
Summary
Collagenous colitis, a rare condition, can affect children and may present with neurological symptoms and brain demyelination. While gastrointestinal issues improve with treatment, neurological problems persist.
Area of Science:
- Pediatric Gastroenterology
- Pediatric Neurology
- Autoimmune Disorders
Background:
- Collagenous colitis (CC) is a rare microscopic colitis primarily affecting adults.
- Pediatric cases of CC are infrequently reported.
- The association between CC and neurological manifestations in children is not well-documented.
Observation:
- Two pediatric patients with collagenous colitis presented with concurrent neurological symptoms.
- Both children exhibited variable neurological signs and significant cerebral demyelination on imaging.
- Gastrointestinal symptoms in both patients responded well to a short course of prednisolone.
Findings:
- The study highlights a potential link between pediatric collagenous colitis and neurological complications.
- Cerebral demyelination was a notable finding in the affected children.
- While gastrointestinal symptoms were responsive to treatment, neurological manifestations were persistent and progressive.
Implications:
- This report suggests a need for increased awareness of potential neurological involvement in pediatric CC.
- Further research is warranted to understand the pathophysiology of this association.
- Early recognition and multidisciplinary management may be crucial for affected children.
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