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Updated: May 10, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Published on: May 10, 2021
Standard examination and adjunctive techniques for detection of oral premalignant and malignant lesions
1Department of Oral and Maxillofacial Pathology, Radiology and Medicine, New York University College of Dentistry, USA. ark3@nyu.edu
Abstract:
This article outlines how to perform a standard comprehensive extraoral and intraoral examination and the existing commercially available adjunctive techniques for the early detection of oral cancer and premalignant lesions. Visualization-based techniques (e.g., autofluorescence and chemiluminescence), toluidine blue vital staining, cytopathologic tests and high-risk human papillomavirus testing are discussed in detail, including the indications and protocols for use, their advantages and disadvantages and clinical cases.
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