Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
Pulmonary Ventilation: Inhalation01:24

Pulmonary Ventilation: Inhalation

Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)
Respiratory Volumes01:15

Respiratory Volumes

Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary and cardiovascular responses to repeated ozone exposure during exercise in adults with exercise-induced bronchoconstriction.

Physiological reports·2026
Same author

Combined multi-metric assessment of diaphragm contractile function in healthy humans: Feasibility, validity and reliability.

Experimental physiology·2026
Same author

Exercise physiology trails the field in sex and gender equity: a call for faster progress, higher standards, and stronger science.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme·2026
Same author

Ultrasonographic evaluation of diaphragm fatigue in healthy humans.

Experimental physiology·2025
Same author

Validity of a wrist-worn consumer-grade wearable for estimating energy expenditure, sedentary behaviour, and physical activity in manual wheelchair users with spinal cord injury.

Disability and rehabilitation. Assistive technology·2024
Same author

Attenuating intrathoracic pressure swings decreases cardiac output at different intensities of exercise.

The Journal of physiology·2023
Same journal

SLIT-ROBO Signaling in Diabetes: A Dual Regulator of Angiogenesis and Vascular Dysfunction.

Comprehensive Physiology·2026
Same journal

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

Comprehensive Physiology·2026
Same journal

The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure.

Comprehensive Physiology·2026
Same journal

Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.

Comprehensive Physiology·2026
Same journal

Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential.

Comprehensive Physiology·2026
Same journal

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases.

Comprehensive Physiology·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

Ventilation and respiratory mechanics.

Andrew William Sheel1, Lee M Romer

  • 1The School of Kinesiology, The University of British Columbia, Vancouver, Canada. bill.sheel@ubc.ca

Comprehensive Physiology
|June 27, 2013
PubMed
Summary
This summary is machine-generated.

Healthy lungs manage exercise demands by regulating breathing and blood flow to maintain gas exchange. This review explores how exercise impacts the pulmonary system and muscle function, including sex-based differences.

More Related Videos

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
13:10

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

Related Experiment Videos

Last Updated: May 10, 2026

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
13:10

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

Area of Science:

  • Physiology
  • Exercise Science
  • Pulmonary Medicine

Background:

  • Dynamic exercise challenges the pulmonary system with altered blood gas levels and reduced capillary transit time.
  • Maintaining blood gas homeostasis requires precise regulation of alveolar ventilation through neural networks and reflexes.
  • Matching cardiovascular and pulmonary responses to metabolic demands is crucial during exercise.

Purpose of the Study:

  • To review the physiological responses of the healthy pulmonary system during dynamic exercise in young adults under normoxia.
  • To examine the influence of exercise-induced hyperpnea on sympathetic vasoconstrictor outflow and muscular work capacity.
  • To discuss sex-based differences in lung mechanics during exercise.

Main Methods:

  • Review of recent scientific evidence and literature.
  • Analysis of physiological data related to gas exchange and cardiovascular function during exercise.
  • Examination of neural and reflex mechanisms controlling ventilation.

Main Results:

  • Exercise increases ventilatory demand and reduces blood transit time in pulmonary capillaries.
  • Precise regulation of alveolar ventilation is essential for blood gas homeostasis.
  • Exercise hyperpnea may affect sympathetic vasoconstrictor outflow and muscular performance.
  • Sex-based differences in lung mechanics exist during exercise.

Conclusions:

  • The pulmonary system employs sophisticated mechanisms to meet the demands of dynamic exercise.
  • Understanding the interplay between ventilation, cardiac output, and gas exchange is key to exercise physiology.
  • Further research into exercise-induced sympathetic activity and sex-based differences in lung mechanics is warranted.