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Compound management: guidelines for compound storage, provision, and quality control
Sue Holland-Crimmin1, Paul Gosnell, Chad Quinn
1Platform Technology and Sciences, GlaxoSmithKline, Collegeville, Pennsylvania.
Current Protocols in Chemical Biology
|June 27, 2013
Summary
Compound management, crucial for drug discovery, involves handling solids and liquids, delivery, automation, quality assurance, and informatics. This guide details best practices for these essential compound management operations.
Area of Science:
- Scientific discipline of compound management
- Drug discovery and development
Background:
- Compound management has seen significant advancements in the last decade.
- Numerous conferences highlight the growing importance of this field.
Purpose of the Study:
- To provide guidelines, best practices, and experimental protocols for key aspects of compound management.
- To consolidate essential information for effective compound handling in scientific research.
Main Methods:
- Management, storage, and processing of solid and liquid compounds.
- Compound delivery systems and customer interfaces.
- Performance evaluation of instruments and automation.
- Analytical techniques for quality assurance.
- Sample informatics: registration, routing, and quality data management.
Main Results:
- Established comprehensive protocols for various compound management operations.
- Highlighted the integration of automation and informatics for efficiency.
- Emphasized the importance of analytical techniques for ensuring compound quality.
Conclusions:
- Effective compound management is critical for the success of research and development.
- Adherence to best practices ensures the integrity and usability of chemical compounds.
- This article serves as a foundational resource for compound management professionals.
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