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Microscopic colitis: a therapeutic challenge.

World Journal of Gastroenterology

|June 27, 2013

Summary

This summary is machine-generated.

Budesonide is the primary treatment for microscopic colitis, but relapses are common after discontinuation. Long-term budesonide avoidance necessitates exploring alternative therapies due to steroid dependence and toxicity concerns.

Keywords:

Budesonide Immunosuppressants Mesalazine Microscopic colitis

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Area of Science:

Gastroenterology
Pharmacology

Background:

Microscopic colitis treatment primarily relies on budesonide, the sole drug proven effective in clinical trials.
Budesonide necessitates maintenance therapy (≤6 mg daily) to prevent relapse after initial treatment (9 mg daily).

Discussion:

Long-term budesonide use raises concerns about steroid dependence and drug toxicity.
Alternative pharmacological agents are needed to mitigate risks associated with indefinite budesonide treatment.

Key Insights:

Current evidence-based guidelines for alternative microscopic colitis treatments are lacking.
Insufficient conclusive data exists regarding immunosuppressive or anti-tumor necrosis factor agents.

Outlook:

Physicians must individualize long-term microscopic colitis management strategies.
Further research is crucial to establish evidence-based guidelines for alternative therapies.