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Updated: May 10, 2026
Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
Red blood cell microparticles: clinical relevance
Olivier Rubin1, Giorgia Canellini, Julien Delobel
1Service Régional Vaudois de Transfusion Sanguine, Epalinges, Switzerland.
Summary:
Microparticles are small phospholipid vesicles of less than 1 µm released into the blood flow by various types of cells such as endothelial, platelet, white or red blood cells. They are involved in many biological and physiological processes including hemostasis. In addition, an elevated number of microparticles in the blood is observed in various pathological situations. In the context of transfusion, erythrocyte-derived microparticles are found in red blood cell concentrates. Their role is not elucidated, and they are considered as a type of storage lesion. The purpose of this review is to present recent data showing that erythrocyte-derived microparticles most likely play a role in transfusion medicine and could cause transfusion complications.
Insights
Erythrocyte-derived microparticles, released from red blood cells, are present in blood transfusions. Emerging evidence suggests these microparticles may contribute to transfusion complications.
Area of Science:
- Hematology
- Transfusion Medicine
- Cellular Biology
Background:
- Microparticles are small vesicles released from various cell types, including red blood cells.
- These particles play roles in physiological processes like hemostasis.
- Elevated microparticle levels are linked to pathological conditions.
Purpose of the Study:
- To review recent data on erythrocyte-derived microparticles in transfusion medicine.
- To explore the potential role of these microparticles in transfusion complications.
Main Methods:
- Literature review of recent studies on erythrocyte-derived microparticles.
- Analysis of data related to microparticle presence in red blood cell concentrates.
Main Results:
- Erythrocyte-derived microparticles are found in stored red blood cell concentrates.
- Their precise function is not fully understood and they are often considered storage lesions.
Conclusions:
- Erythrocyte-derived microparticles are increasingly recognized as significant in transfusion medicine.
- These microparticles may be implicated in adverse transfusion reactions.
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