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Updated: May 10, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
Published on: May 18, 2018
IL-10 control of dendritic cells in the skin
Björn E Clausen1, Mathilde J H Girard-Madoux
1Department of Immunology; Erasmus MC; University Medical Center; Rotterdam, The Netherlands ; Institute for Molecular Medicine; University Medical Center of the Johannes Gutenberg-University; Mainz, Germany.
Abstract:
Interleukin-10 (IL-10) is a potent immunomodulatory cytokine, whose cellular targets have not yet been precisely identified. Dendritic cell (DC)-specific IL-10 receptor knockout mice exhibit exaggerated T-cell reactivation in the skin, highlighting a key role of DCs in the maintenance of local immune homeostasis, beyond their classical function as regulators of T-cell priming in lymph nodes.
