Related Experiment Video
Updated: May 10, 2026

09:30
Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice
Published on: October 3, 2025
Misophonia: physiological investigations and case descriptions
Miren Edelstein1, David Brang, Romke Rouw
1Department of Psychology, Center for Brain and Cognition, University of California, San Diego San Diego, CA, USA.
Frontiers in Human Neuroscience
|June 28, 2013
Summary
Misophonia causes intense autonomic arousal to specific sounds, leading to distress and social challenges. This study found misophonic individuals exhibit distinct physiological responses to auditory triggers, differentiating them from controls.
Area of Science:
- Neuroscience
- Psychology
- Audiology
Background:
- Misophonia is a chronic condition characterized by strong negative emotional and physiological responses to specific sounds.
- Trigger sounds, often innocuous and repetitive (e.g., chewing, pen clicking), provoke an involuntary "fight-or-flight" autonomic arousal in affected individuals.
- This condition significantly impacts daily functioning and social interactions due to the distress caused by trigger sounds.
Purpose of the Study:
- To investigate the behavioral and physiological characteristics of misophonia.
- To explore the nature of trigger sounds and coping mechanisms employed by individuals with misophonia.
- To test the hypothesis that misophonia involves anomalous physiological responses to auditory stimuli.
Main Methods:
- Experiment 1 involved interviews with misophonic individuals to identify common trigger sounds and behavioral patterns.
- Experiment 2 measured behavioral (subjective ratings) and physiological (skin conductance responses - SCRs) reactions to auditory and visual stimuli in misophonic and control groups.
- Participants included individuals with misophonia and typically developed controls.
Main Results:
- Interviews revealed that sounds associated with others' behaviors (e.g., chewing) are most problematic, with individuals not reacting to self-produced sounds.
- Misophonic individuals reported heightened subjective distress and exhibited increased skin conductance responses (SCRs) to auditory stimuli compared to controls.
- No significant differences in responses were observed for visual stimuli between the groups.
Conclusions:
- Misophonia is characterized by distinct autonomic responses to specific auditory triggers, differentiating affected individuals from the general population.
- The findings support the view of misophonia as a disorder with unique physiological underpinnings.
- Auditory stimuli, not visual, appear to be the primary drivers of the anomalous physiological responses observed in misophonia.

