Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 10, 2026

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point
03:13

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

Published on: June 28, 2024

Pathologic investigation failure of trabeculotomy.

Yoko Amari1, Teruhiko Hamanaka, Ryusuke Futa

  • 1*Department of Ophthalmology, Japanese Red Cross Medical Center, Tokyo †Hikuma Eye Clinic, Kumamoto, Japan.

Journal of Glaucoma
|June 29, 2013
PubMed
Summary

Trabeculotomy failure in glaucoma is linked to scar tissue and Schlemm canal occlusion, not just the initial surgical opening. Histologic changes in the trabecular meshwork impede the long-term success of this glaucoma surgery.

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive, High-Spatiotemporal-Resolution Intravital Two-Photon Imaging of the Mouse Conventional Outflow Pathway: Green Intravital Imaging.

Investigative ophthalmology & visual science·2026
Same author

Correlation between mid-term intraocular pressure and aqueous flare value in micropulse transscleral cyclophotocoagulation: a retrospective observational study.

BMC ophthalmology·2026
Same author

Possible Effects of Topical Rho-Kinase Inhibitor on Schlemm's Canal Morphology Parameters.

Biomedicines·2026
Same author

Quantitative Evaluation of Trabecular Meshwork in Normal Tension Glaucoma Using Trabecular Meshwork Analyzing Software.

American journal of ophthalmology·2025
Same author

Historical and Contemporary Debates in Schlemm's Canal-Based MIGS.

Journal of clinical medicine·2024
Same author

Mutations of CYP1B1 and FOXC1 genes for childhood glaucoma in Japanese individuals.

Japanese journal of ophthalmology·2024

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Surgical Pathology

Background:

  • Trabeculotomy is a surgical procedure to lower intraocular pressure (IOP) in glaucoma.
  • Understanding the reasons for trabeculotomy failure is crucial for improving glaucoma treatment outcomes.

Purpose of the Study:

  • To investigate the histological reasons for the failure of trabeculotomy surgery.
  • To analyze trabeculectomy (TLE) specimens from patients who previously underwent trabeculotomy.

Main Methods:

  • Examined 13 TLE specimens from patients with open-angle glaucoma using light and transmission electron microscopy.
  • Performed immunohistochemical staining for thrombomodulin, D2-40 (podoplanin), and CD34.
  • Analyzed tissue from both peripheral anterior synechia (PAS) and non-PAS areas.

Related Experiment Videos

Last Updated: May 10, 2026

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point
03:13

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

Published on: June 28, 2024

Main Results:

  • Intraocular pressure initially decreased post-trabeculotomy but returned to pre-operative levels or higher.
  • Observed four types of trabecular meshwork changes: persistent disconnection, fusion, membrane covering, and pigmented cell invasion.
  • Schlemm canal (SC) opening into the anterior chamber was noted in 2 eyes, while SC occlusion occurred in 8 eyes.

Conclusions:

  • Histological changes in the trabecular meshwork, including scar formation and occlusion, likely impede the effectiveness of newly created unconventional routes after trabeculotomy.
  • The patency of Schlemm canal into the anterior chamber may not be the sole determinant of the IOP-lowering effect of trabeculotomy.