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Updated: May 10, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Cardiac resynchronization therapy in cardiomyopathies

Daniele Masarone1, Giuseppe Limongelli, Ernesto Ammendola

  • 1aMonaldi Hospital, Second University of Naples, Naples, Italy bThe Heart Hospital, University College Hospital and Institute of Cardiovascular Sciences, London, UK.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|July 2, 2013
PubMed

Insights

Cardiac resynchronization therapy (CRT) is vital for heart failure but its use in various cardiomyopathies beyond dilated cardiomyopathy requires further investigation. This review explores the latest evidence on CRT efficacy in diverse cardiomyopathy types.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology

Background:

  • Cardiomyopathies are myocardial diseases causing significant morbidity and mortality from heart failure and sudden death.
  • Cardiac resynchronization therapy (CRT) is a key treatment for heart failure.

Purpose of the Study:

  • To review the current evidence on the application of CRT in various forms of cardiomyopathies.
  • To highlight areas where CRT's role is established and where further research is needed.

Main Methods:

  • Review of recent scientific literature and clinical trial data.
  • Analysis of CRT efficacy across different cardiomyopathy subtypes.

Main Results:

  • CRT is highly effective in patients with dilated cardiomyopathy.
  • The role and efficacy of CRT in other cardiomyopathies, such as hypertrophic or arrhythmogenic cardiomyopathy, are still under investigation.

Conclusions:

  • CRT is an established therapy for specific heart failure patients with reduced ejection fraction and conduction delays.
  • Further research is essential to define optimal CRT strategies for non-dilated cardiomyopathies.

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