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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Imidazoles as potential antifungal agents: a review
Nidhi Rani1, Ajay Sharma, Girish Kumar Gupta
1Himalayan Institute of Pharmacy, Kala-Amb, Distt. Sirmour, Himachal Pradesh, India. nidhiprajapati8@gmail.com
Abstract:
Imidazoles are one of the most promising and vigorously pursued areas of contemporary antifungal chemotherapy depicting broad spectrum and potent activity. They have relatively simple molecular nucleus, which is amenable to many structural modifications. These agents have several favorable properties such as excellent bioavailability, good tissue penetrability and permeability and a relatively low incidence of adverse and toxic effects. They have been found effective in the treatment of various infectious diseases. This paper is an attempt to review the therapeutic potential of imidazoles as antifungal with an updated account on their development.
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