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Related Experiment Video

Updated: May 10, 2026

Collection Protocol for Human Pancreas
07:49

Collection Protocol for Human Pancreas

Published on: May 23, 2012

Extended pancreas donor program - the EXPAND study rationale and study protocol.

Andrea Proneth1, Andreas A Schnitzbauer, Florian Zeman

  • 1Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. stefan.farkas@ukr.de.

Transplantation Research
|July 3, 2013
PubMed
Summary

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This summary is machine-generated.

This study explores using extended criteria donor organs for pancreas transplantation to expand the donor pool. It aims to show similar outcomes, potentially reducing waitlist morbidity and mortality for diabetic patients.

Area of Science:

  • Nephrology
  • Transplantation
  • Endocrinology

Background:

  • Pancreas transplantation is a curative option for type 1 diabetes, but limited donor criteria increase waitlists.
  • Restrictive donor criteria (age <50, BMI <30) in the Eurotransplant area limit organ availability.
  • Increased waitlist time correlates with higher morbidity and mortality for transplant candidates.

Purpose of the Study:

  • To investigate if extended criteria donor organs can be safely transplanted for pancreas, kidney, or simultaneous pancreas-kidney transplantation.
  • To determine if using extended criteria organs can increase the donor pool and reduce waitlist times.
  • To compare transplant outcomes between standard and extended criteria donor organs.

Main Methods:

  • A prospective, multicenter, single-blinded, non-randomized trial comparing standard vs. extended criteria donor organs.

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  • Extended criteria defined as donor BMI 30-34 or age 50-60 years.
  • Primary endpoint: pancreas allograft survival and function at three months post-transplant.

    • Main Results:

    • The study is initiated to test the hypothesis of similar outcomes with extended criteria organs.
    • A favorable comparison could lead to reduced patient morbidity and mortality.
    • The EXPAND study (NCT01384006) aims to validate expanded donor criteria.

    Conclusions:

    • The EXPAND study hypothesizes that extended criteria donor organs can be transplanted effectively.
    • Successful validation may expand the donor pool and improve outcomes for patients awaiting pancreas transplantation.
    • This research could significantly reduce waitlist complications and mortality.