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Published on: September 12, 2016
Filgrastim therapy in a child with neutropenia induced by linezolid
Marta Hernández Segurado1, Maria Ángeles Arias Moya, Marta Gómez Pérez
1Pharmacy Service, Fundación Jiménez Díaz University Hospital, Avenue Reyes Católicos, 2, 28040, Madrid, Spain. mhernandezs@fjd.es
Abstract:
We describe the case of a young child with multidrug-resistant tuberculosis, treated with linezolid. The child developed severe neutropenia after 5 months of treatment. Filgrastim was used, a drug that officially is not indicated for non-cytostatic drug-induced neutropenia. This allowed the fast recovery of the patient's neutrophil-count. However, more experience with the off-label use of filgrastrim is needed in the pediatric population.