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Malignant transformation in fibrous dysplasia. A report of 3 cases
R Chetty1, M R Kalan, D H Kranold
1Department of Anatomical Pathology, University of Cape Town.
Abstract:
Three patients with fibrous dysplasia were encountered in whom osteosarcoma subsequently developed. A review of published reports and the authors' experience establishes fibrous dysplasia as a premalignant bone lesion. Radiation appears to enhance the inherent tendency towards malignant transformation.