JADA: a graphical user interface for comprehensive internal dose assessment in nuclear medicine

Area of Science:

• Medical Physics
• Nuclear Medicine
• Radiological Sciences

Background:

• Accurate internal dosimetry is crucial for radiation therapy and nuclear medicine procedures.
• Existing dosimetry methods often involve complex, multi-step processes with manual data handling.
• A unified software environment can enhance efficiency and reduce errors in dose calculations.

Purpose of the Study:

• To develop a comprehensive dosimetry software package within a single environment.
• To support various internal dose calculation approaches for different imaging modalities.
• To streamline the entire process of internal dose assessment.

Main Methods:

• A MATLAB-based graphical user interface (GUI) was developed.
• The software processes data from planar, SPECT, and hybrid imaging.
• Tools for image reconstruction, coregistration, segmentation, and time-activity curve fitting are included.

Main Results:

• The software provides organ-level dose calculations comparable to OLINDA/EXM.
• Voxelized dose calculation options include the voxel S value approach.
• Monte Carlo simulations using DOSXYZnrc are integrated for advanced dose assessment.

Conclusions:

• The developed software package consolidates all internal dose calculation steps.
• It eliminates manual data transfer, saving time and minimizing user errors.
• The versatile package enables efficient, patient-specific internal dose calculations in clinical settings.