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[Serum lactoferrin level in normal conditions and in pathology]
Voprosy Meditsinskoi Khimii
|May 1, 1990
Summary
Lactoferrin levels in human blood serum varied significantly with disease. Higher lactoferrin was found in lymphogranulomatosis, colon cancer, and pneumonia, but lower in liver disease and prostate cancer.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Immunology
Background:
- Lactoferrin is an iron-binding protein with antimicrobial and immunomodulatory functions.
- Serum lactoferrin levels can be altered in various physiological and pathological conditions.
Purpose of the Study:
- To quantify lactoferrin levels in human serum across healthy individuals and patients with diverse diseases.
- To investigate the association between serum lactoferrin concentration and specific tumoral and non-tumoral conditions.
Main Methods:
- Immunoenzymatic assay was employed for lactoferrin quantification.
- Serum samples were analyzed from 292 healthy subjects and 518 patients with various diseases.
Main Results:
- Elevated lactoferrin concentrations were observed in lymphogranulomatosis, malignant colon tumors, and acute pneumonia.
- Decreased lactoferrin levels were noted in patients with liver tissue impairments and prostate cancer.
Conclusions:
- Serum lactoferrin levels serve as a potential biomarker for certain diseases, including specific cancers and infections.
- Further research is warranted to explore the diagnostic and prognostic value of lactoferrin in clinical settings.