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Updated: May 10, 2026
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Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
Published on: March 25, 2020
[Multicentre study on hepatic adenomas]
José Manuel Ramia1, Carmen Bernardo2, Andrés Valdivieso3
1Unidad Hepatobiliopancreática, Servicio de Cirugía, Hospital Universitario de Guadalajara, Guadalajara, España.
Cirugia Espanola
|July 6, 2013
Summary
Resected hepatic adenomas (HA) are typically large lesions in women, with surgery showing low morbidity and no mortality. Current management strategies are evolving based on lesion size and risk factors.
Area of Science:
- Hepatobiliary surgery
- Gastroenterology
- Surgical oncology
Context:
- Hepatic adenomas (HA) are benign liver tumors that can cause serious complications.
- Historically, all HAs were surgically resected.
- Recent evidence suggests that smaller HAs (<3 cm) not expressing β-catenin have a low complication rate, prompting a shift in therapeutic strategies.
Purpose:
- To analyze the characteristics and outcomes of patients who underwent resection for hepatic adenomas.
- To evaluate surgical techniques, complications, and long-term results in a large cohort of HA patients.
Summary:
- A retrospective study of 81 patients with resected HA between 1995-2011 revealed that most patients were women (75%) with large lesions (median 8.8 cm).
- Symptoms were present in 51%, with abdominal pain being most common. Acute abdomen due to rupture/hemorrhage occurred in 10%.
- Major hepatectomy was performed in 22%, minor hepatectomy in 77%, with 20% laparoscopic approaches. Morbidity was 28%, mortality was 0%, and malignancy occurred in 3.7%.
Impact:
- This study highlights the typical profile of patients undergoing HA resection and provides valuable data on surgical outcomes.
- It underscores the importance of accurate preoperative diagnosis and the evolving management of HAs.
- The findings support current therapeutic strategies and emphasize the safety of surgical intervention for HAs, with low morbidity and no mortality.
