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Everolimus's influence on persistent acute rejection after experimental lung transplantation
Elisabeth Brunner1, Karla Lehle, Stephan W Hirt
1Department of Cardiothoracic Surgery, University of Regensburg, Germany.
Summary
Everolimus, an anti-rejection drug, reduced inflammation in rat lung transplants but did not prevent acute rejection. Further research is needed to optimize lung transplant outcomes and patient survival.
Area of Science:
- Immunology
- Transplantation Medicine
- Pharmacology
Background:
- Acute rejection episodes in lung transplantation heighten the risk of chronic rejection.
- Optimizing acute rejection treatment is crucial for improving long-term lung transplant outcomes and patient survival.
Purpose of the Study:
- To investigate if Everolimus, a mammalian target of rapamycin inhibitor, could mitigate persistent acute rejection following left lung allotransplantation in rats.
Main Methods:
- Rats underwent left lung allotransplantation (F344-to-WKY) and received methylprednisolone with or without Everolimus.
- Immunohistochemistry was used to quantify inflammatory cell infiltration (ED1, CD11a, CD18) and endothelial cell activation (ICAM-1).
Main Results:
- Everolimus significantly reduced ICAM-1 positive small vessels, leukocytes (CD11a, CD18), and macrophages (ED1) in lung allografts by postoperative day 30.
- Despite these anti-inflammatory effects, allografts exhibited severe acute vascular rejection and significant small airway inflammation.
Conclusions:
- Everolimus demonstrated anti-inflammatory properties in rat lung allografts.
- However, these effects did not delay the progression of acute rejection in this model.
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