Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disruption of Epidemic Patterns in Community-Acquired Respiratory Infections Post-Covid-19 in France: A 5-Year Analysis Using the French Pediatric and Ambulatory Research of Infectious Diseases Network.

The Pediatric infectious disease journal·2025
Same author

Impact of Respiratory Syncytial Virus Immunization on the Rate of Pediatric Acute Otitis Media: A Time-series Analysis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

Diagnostic value of preoperative joint aspiration for periprosthetic shoulder infection: analysis of microbiological aspects and preoperative ICM minor criteria.

Archives of orthopaedic and trauma surgery·2025
Same author

Characteristics of Children Hospitalized for Acute COVID-19 in France From February 2020 to December 2023.

The Pediatric infectious disease journal·2025
Same author

Did the resurgence of childhood lower respiratory infections offset the initial benefit of COVID-19-related non-pharmaceutical interventions in children? A time-series analysis.

BMC medicine·2025
Same author

Comparing NIRS and Pulse Oximetry for Cerebral Oxygen Saturation During Hypoxia Testing.

Medical sciences (Basel, Switzerland)·2024
Same journal

Intra- and inter-biosynthetic gene cluster allelic variation as drivers of chemical diversification in Streptomyces.

Essays in biochemistry·2026
Same journal

Considering internal conflict in the face of natural product biosynthesis and biosynthetic gene cluster evolution.

Essays in biochemistry·2026
Same journal

The plant holobiont: integrating molecular priming and ecological legacies for climate-adaptive immunity.

Essays in biochemistry·2026
Same journal

Bacterial-fungal interactions: connections and consequences.

Essays in biochemistry·2026
Same journal

Invasive plasmids as ecosystem engineers-from mechanism to application.

Essays in biochemistry·2026
Same journal

From early defence priming to lasting memory: developmental and seasonal dynamics in trees.

Essays in biochemistry·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
10:21

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

The functions of natural antisense transcripts.

Megan Wight1, Andreas Werner

  • 1Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle NE2 4HH, UK.

Essays in Biochemistry
|July 9, 2013
PubMed
Summary
This summary is machine-generated.

Natural antisense transcripts (NATs) regulate gene expression through interactions with sense transcripts. These regulatory RNAs play crucial roles in various biological processes, making them a key area of research.

More Related Videos

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Related Experiment Videos

Last Updated: May 10, 2026

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
10:21

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Area of Science:

  • Molecular Biology
  • Genetics
  • RNA Biology

Background:

  • Natural antisense transcripts (NATs) are prevalent in eukaryotic genomes.
  • NATs interact with sense transcripts, indicating a role in gene expression regulation.
  • NATs can also cause transcriptional interference, immune responses, or gene silencing.

Purpose of the Study:

  • To highlight the regulatory roles of NATs in gene expression.
  • To emphasize the emerging mechanisms and biological significance of NATs.
  • To underscore the importance of NATs as modulators of gene expression.

Main Methods:

  • Literature review on NATs.
  • Analysis of experimental evidence on NAT-sense transcript interactions.
  • Examination of NATs' roles in gene silencing and transcriptional interference.

Main Results:

  • NATs are significant modulators of gene expression.
  • Tissue-specific expression and cellular compartmentalization enhance NATs' regulatory impact.
  • Emerging research continually reveals new functions and biological roles for NATs.

Conclusions:

  • NATs are crucial regulators of gene expression with diverse mechanisms.
  • The field of regulatory RNAs, including NATs, is rapidly advancing.
  • NATs are integral to understanding complex gene regulatory networks.