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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

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Published on: November 4, 2010

Exercise-induced bronchoconstriction: celebrating 50 years.

Simon Godfrey1, Kenneth D Fitch

  • 1Hadassah Hebrew University, Jerusalem, Israel. sgodfrey@netvision.net.il

Immunology and Allergy Clinics of North America
|July 9, 2013
PubMed
Summary
This summary is machine-generated.

Researchers have studied exercise-induced bronchoconstriction for over 50 years, but its exact cause remains elusive. Future investigations are needed to fully understand this condition and develop effective treatments.

Keywords:
Airway coolingAirway dryingAsthmaAthletesBronchoconstrictionExerciseHistorical reviewRefractory period

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Area of Science:

  • Pulmonary Medicine
  • Exercise Physiology
  • Respiratory Research

Background:

  • Investigating the causes of exercise-induced bronchoconstriction (EIB) has been a focus for over fifty years.
  • Numerous international research efforts have aimed to understand the mechanisms behind EIB.

Observation:

  • Despite extensive research, the precise causation of EIB remains incompletely understood.
  • Key questions regarding the triggers and pathways of EIB persist.

Findings:

  • A comprehensive review of historical research on EIB causation is presented.
  • The article highlights the significant progress made while acknowledging persistent knowledge gaps.

Implications:

  • Further research is essential to fully elucidate the complex mechanisms of EIB.
  • Future studies will build upon decades of work to provide definitive answers.
  • Understanding EIB causation is crucial for improving patient management and treatment strategies.