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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

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A parallel overset-curvilinear-immersed boundary framework for simulating complex 3D incompressible flows.

Iman Borazjani¹, Liang Ge, Trung Le

¹Department of Mechanical and Aerospace Engineering, SUNY University at Bu alo, NY, USA.

Computers & Fluids

|July 9, 2013

Summary

A new overset-curvilinear immersed boundary (overset-CURVIB) method simulates complex biological flows. This versatile computational fluid dynamics approach enhances resolution for deforming bodies and multi-connected geometries.

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Area of Science:

Computational fluid dynamics
Biomedical engineering
Numerical analysis

Background:

Simulating complex biological flows requires methods that handle intricate geometries and large deformations.
Existing immersed boundary methods may face limitations with multi-connected domains and local resolution.
General non-inertial frames of reference are crucial for versatile and efficient simulations.

Purpose of the Study:

To develop and implement an overset-curvilinear immersed boundary (overset-CURVIB) method.
To enhance the simulation of challenging biological flow problems with complex geometries.
To improve local resolution near immersed boundaries for deforming bodies.

Main Methods:

Incorporation of overset-curvilinear grids for multi-connected geometries.
Utilizing the curvilinear immersed boundary (CURVIB) method for sharp interfaces.
Formulation of incompressible flow equations in a general non-inertial frame.
Development of efficient search algorithms and parallel computing strategies.
Second-order accurate finite-volume discretization and fractional-step time integration.
Implementation and evaluation of globally conservative interpolation strategies.

Main Results:

The overset-CURVIB method efficiently handles multi-connected geometries and local resolution.
Complex bodies with large deformations are accurately represented as sharp interfaces.
Efficient parallel computing strategies facilitate information transfer among sub-domains.
The method is verified and validated against experimental data.
Demonstrated capabilities in simulating aquatic swimmer flows and cardiac flows.

Conclusions:

The overset-CURVIB method provides a versatile and efficient tool for simulating complex biological flows.
The approach effectively addresses challenges related to geometry, deformation, and resolution.
Validated simulations show promise for applications in biomechanics and medical device design.