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Cyclic voltammetric study of lorazepam.
J Rosas1, J M Pinilla, L Hernández
1Dpto. Quimica (Area de Analítica), Facultad de Ciencias Universidad Autónoma de Madrid, Spain.
Farmaco (Societa Chimica Italiana : 1989)
|March 1, 1990
Summary
Cyclic voltammetry effectively determined lorazepam in pharmaceuticals. Optimized conditions yielded high accuracy, with errors under 3% and standard deviations under 2%.
Area of Science:
- Electrochemistry
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Lorazepam is a widely prescribed benzodiazepine medication.
- Accurate quantification of lorazepam in pharmaceutical formulations is crucial for quality control.
Purpose of the Study:
- To investigate the electrochemical behavior of lorazepam using cyclic voltammetry.
- To develop and validate a novel method for lorazepam determination in pharmaceutical preparations.
Main Methods:
- Cyclic voltammetry was employed to study lorazepam.
- Optimal parameters were identified as pH 7 and a sweep rate of 600 mV/s.
- The method was applied to analyze lorazepam in various pharmaceutical samples.
Main Results:
- Well-defined cyclic voltammograms for lorazepam were obtained under specific conditions.
- The developed method demonstrated high precision and accuracy.
- Relative errors were consistently below 3%, and relative standard deviations were less than 2%.
Conclusions:
- Cyclic voltammetry provides a reliable method for lorazepam analysis.
- The proposed method is suitable for the quality control of lorazepam in pharmaceutical products.
- This electrochemical approach offers an efficient alternative for lorazepam quantification.