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Baclofen in the treatment of persistent hiccup: a case series

A Mirijello¹, G Addolorato, C D'Angelo

¹Department of Internal Medicine, Catholic University of Rome, Italy.

International Journal of Clinical Practice

|July 10, 2013

Abstract

Background:

Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.

Aim:

To test baclofen administration for the treatment of persistent hiccup.

Method:

We report a series of seven patients affected by persistent hiccup successfully treated with baclofen.

Results:

Hiccup stopped in all patients after a single administration of the drug.

Conclusions:

Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.

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