Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.

ACS biomaterials science & engineering·2026
Same author

Bridging the gap: towards a digital twin to optimize therapeutic cell-seeding strategies in nerve tissue engineering.

Journal of the Royal Society, Interface·2026
Same author

Decellularization of porcine small-diameter vascular grafts: evaluation of a latrunculin B-based method and novel perfusion approach.

Biofabrication·2026
Same author

Peptides Targeting GDNF Family Receptor Alpha 1 (GFRα1) Mimic Glial Cell Line-Derived Neurotrophic Factor (GDNF) Bioactivity.

Journal of medicinal chemistry·2026
Same author

Evaluation of a GDNF-eluting nanofibrous PCL conduit in a mouse model of peripheral nerve injury.

RSC advances·2026
Same author

Advanced three-dimensional in vitro models for Parkinson's disease research.

Neural regeneration research·2026

Related Experiment Video

Updated: May 9, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Engineered neural tissue for peripheral nerve repair.

Melanie Georgiou1, Stephen C J Bunting, Heather A Davies

  • 1The Open University, Walton Hall, Milton Keynes, UK.

Biomaterials
|July 10, 2013
PubMed
Summary
This summary is machine-generated.

Researchers developed a new method using Schwann cells and collagen to create aligned neural tissue for nerve repair. This engineered tissue successfully promoted nerve regeneration in animal models, offering a promising solution for peripheral nerve injuries.

Keywords:
CollagenHydrogelNerve guideNerve regenerationNerve tissue engineeringSchwann cell

More Related Videos

Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat
10:35

Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat

Published on: February 25, 2020

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
10:17

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering

Published on: May 16, 2022

Related Experiment Videos

Last Updated: May 9, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat
10:35

Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat

Published on: February 25, 2020

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
10:17

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering

Published on: May 16, 2022

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Neuroscience

Background:

  • Peripheral nerve injuries often require grafts to bridge nerve gaps.
  • Existing nerve graft methods face limitations in promoting regeneration and functional recovery.
  • Engineered neural tissues aim to mimic native nerve structure and function.

Purpose of the Study:

  • To develop a simple and effective method for creating aligned cellular biomaterials.
  • To fabricate artificial neural tissue for peripheral nerve repair using Schwann cells.
  • To assess the efficacy of engineered neural tissue in supporting neuronal growth in vitro and in vivo.

Main Methods:

  • Utilizing a combination of tissue engineering techniques, including self-alignment of Schwann cells within a tethered type-1 collagen matrix.
  • Employing interstitial fluid removal to stabilize the engineered biomaterial.
  • Evaluating neuronal growth in a co-culture model and in rat sciatic nerve repair models with varying gap sizes (5 mm and 15 mm).

Main Results:

  • The engineered neural tissue successfully mimicked the aligned cellular and extracellular matrix architecture of nerve grafts.
  • Sheets of engineered neural tissue supported and directed neuronal growth in co-culture.
  • In vivo studies demonstrated robust neuronal regeneration across a critical-sized 15 mm gap in rat sciatic nerves within 8 weeks.

Conclusions:

  • This novel approach provides a useful method for generating anisotropic engineered tissues.
  • The engineered neural tissue fabricated with Schwann cells shows significant potential for peripheral nerve repair.
  • The technique offers a promising strategy for creating functional artificial neural tissue grafts.