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Updated: May 9, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Cutaneous angiosarcoma: a single-institution experience.

Matthew C Perez1, Tapan A Padhya, Jane L Messina

  • 1Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Annals of Surgical Oncology
|July 10, 2013
PubMed
Summary
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Cutaneous angiosarcoma (CAS) survival rates are better than previously thought, particularly for trunk/extremity cases. Smaller tumor size (<5 cm) is linked to improved overall survival in CAS patients.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Dermatopathology

Background:

  • Cutaneous angiosarcoma (CAS) is a rare, aggressive vascular tumor.
  • Historically, 5-year survival rates for CAS range from 10-30%.

Purpose of the Study:

  • To analyze outcomes and prognostic factors for patients with CAS.
  • To compare survival rates across different CAS subtypes and treatment modalities.

Main Methods:

  • Retrospective review of 88 CAS patients treated between 1999-2011.
  • Analysis of demographics, tumor characteristics, treatments (surgery, radiation therapy), and survival outcomes.
  • Multivariate analysis to identify significant prognostic factors.

Main Results:

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Last Updated: May 9, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

  • 5-year overall survival (OS) and recurrence-free survival (RFS) were 35.2% and 32.3%, respectively.
  • Surgery alone showed higher OS (46.9%) and RFS (39.9%) but not statistically significant.
  • CAS on trunk/extremities had the best 5-year OS (64.8%), while head/neck CAS had the worst (21.5%).
  • Tumor size <5 cm was a significant predictor of improved OS.

    • Conclusions:

    • CAS prognosis may be better than historically reported, especially for trunk/extremity and Stewart-Treves types.
    • Surgery alone may offer better outcomes, though not statistically significant in this study.
    • Tumor size is a critical prognostic factor for overall survival in cutaneous angiosarcoma.