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Updated: May 9, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Evolving pharmacotherapies for the treatment of metastatic melanoma
1Division of Medical Oncology, Duke University Medical Center, Durham NC, USA.
Abstract:
Metastatic melanoma remains a difficult disease to treat, and long term survivors are rare. Over the past few years, however, breakthroughs in both immunotherapy as well as targeted agents have had a tremendous impact on patients diagnosed with this disease. This review summarizes recent advances in systemic therapies for melanoma, including immune modulators directed against cytotoxic T lymphocyte associated antigen-4 (CTLA-4) and programmed death-1 (PD-1), as well as a number of targeted agents. These approaches hold great promise as the landscape of therapeutic options for advanced melanoma continues to evolve.
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