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Related Experiment Video

Updated: May 9, 2026

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

CMOS Amperometric Instrumentation and Packaging for Biosensor Array Applications.

Lin Li, Xiaowen Liu, W A Qureshi

    IEEE Transactions on Biomedical Circuits and Systems
    |July 16, 2013
    PubMed
    Summary
    This summary is machine-generated.

    This study presents an integrated CMOS amperometric instrument for biosensor arrays. The device offers high resolution and programmable settings, matching commercial instrument performance for electrochemical measurements.

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    Published on: April 18, 2013

    Area of Science:

    • * Integrated Circuit Design
    • * Biosensor Technology
    • * Electrochemistry

    Background:

    • * Development of miniaturized electrochemical instruments is crucial for advanced biosensor arrays.
    • * Existing instruments often lack integration, programmability, and high resolution.
    • * Need for robust packaging solutions compatible with various testing environments and cleaning processes.

    Purpose of the Study:

    • * To present an integrated CMOS amperometric instrument with on-chip electrodes and packaging for biosensor arrays.
    • * To demonstrate the instrument's capability to support diverse electrochemical measurement techniques.
    • * To validate the performance of the developed instrument against commercial standards.

    Main Methods:

    • * Design and fabrication of a mixed-signal integrated circuit in 0.5 μm CMOS technology.
    • * Integration of a 2 × 2 gold electrode array on the CMOS chip.
    • * Development of an all-parylene packaging scheme for liquid and harsh cleaning compatibility.
    • * Testing using cyclic voltammetry with potassium ferricyanide solutions at varying concentrations and scan rates.

    Main Results:

    • * The 3 × mm(2) chip operates at 22.5 mW with a 200 kHz clock.
    • * The instrument supports programmable stimulus rates and amplitudes, with a 2 V scan range and scan rates from 1 mV/sec to 400 V/sec.
    • * Amperometric readout achieves ±500 fA linear resolution and supports inputs up to ±47 μA.
    • * Cyclic voltammetry results using the integrated instrument were identical to those obtained with commercial instruments.

    Conclusions:

    • * The presented integrated CMOS amperometric instrument offers a high-performance, miniaturized solution for biosensor arrays.
    • * The developed on-chip electrodes and parylene packaging ensure compatibility and robustness.
    • * The instrument's performance is validated and comparable to commercial systems, paving the way for advanced electrochemical sensing applications.