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Non-familial Cherubism.

Virendra Kumar Prajapati1

  • 1Associate Professor and HOD, Department of Dentistry, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.

Contemporary Clinical Dentistry
|July 16, 2013
PubMed
Summary
This summary is machine-generated.

Cherubism is a rare genetic disorder causing jaw enlargement in children. This case study details an 8-year-old experiencing this condition without a family history.

Keywords:
Bilateral jaw swellingCherubismgiant cell lesion

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Pediatric Dentistry
  • Clinical Genetics

Background:

  • Cherubism is a rare, benign, autosomal dominant disorder.
  • Characterized by progressive, bilateral, and symmetrical enlargement of the jaw.
  • Typically presents in early childhood with characteristic radiographic and histopathological findings.

Observation:

  • An 8-year-old child presented with features suggestive of cherubism.
  • The patient had no prior family history of the genetic disorder.
  • Clinical examination revealed significant jaw enlargement.

Findings:

  • Radiographic imaging demonstrated diffuse, bilateral, multilocular bony enlargement of the jaws.
  • Histopathological examination confirmed the typical features of cherubism.
  • Genetic analysis was performed to investigate potential mutations.

Implications:

  • This case highlights the importance of recognizing cherubism in pediatric patients, even without a family history.
  • Early diagnosis and management are crucial for optimal outcomes.
  • Further research into the genetic basis of sporadic cherubism cases is warranted.