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Updated: May 9, 2026
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
[Analysis of the human papillomavirus in laryngeal squamous cell carcinoma patients]
Wei Wei1, Yun-tao Song, Bao-yun Zhang
1Head and Neck Surgery Department, Peking University Cancer Hospital & Institute, Beijing, China.
Objective:
To analyze the infection of human papillomavirus in laryngeal squamous cell carcinoma patients.
Methods:
The pathological samples of 64 clinical diagnosed laryngeal squamous cell carcinoma patients were collected. Lunimex and PCR techniques were used to detect the HPV gene infection and immunohistochemistry method was used to analyze the HPV protein expression in the samples.
Results:
In the 64 cases, 7 were positive for HPV infection by Luminex and PCR tests. 18 were positive for HPV16/18 E6 protein expression. The total positive rate was about 39. 1%.
Conclusion:
The high HPV infection rate in laryngeal squamous cell carcinoma patients in the study indicated indirectly that the importance of the HPV infection in pathogenesis of the laryngeal squamous cell carcinoma.
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