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Updated: May 9, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
[The preliminary study of HBV genotype distribution and the relationship with clinical manifestation]
Jing Sun1, Zhi-Yuan Jia, Jun-Xia Chang
1Luhe Hospital, Beijing 101149, China. 13720062144@163.com
Objective:
To explore the relationship between HBV genotypes distribution in hepatitis B patients and clinical manifestations in Beijing area.
Methods:
200 HBsAg positive serum were choosen from 1148 serum samples. useing of nested PCR amplification method, HBV DNA S genes were Sequencing and typing; genotype distribution and the relationship with the clinical manifestation were Statistical analysis.
Results:
In Beijing area, HBV has B, C, D three genotypes, including B gene type 17 cases (12. 5%), C genotype 116 cases (85.2%), D genotype 3 cases (0.02%); in the carriers, patients with chronic hepatitis B, cirrhosis, liver cancer, B type have been gradually falling, C type have been gradually rising trend.
Conclusion:
Serious liver disease relate with C type, B type patients with HBV infection is better than C type patients in clinical prognosis and antivirus treatment response.
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